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. 2011 Mar 16;36(7):1319–1331. doi: 10.1038/npp.2011.8

Figure 8.

Figure 8

Effect of direct serotonin 1A receptor (5-HT1A-R) agonist pretreatment on quinpirole-induced behaviors. Adolescent animals received daily injections of 8-OH-DPAT ((+/−)-8-hydroxy-2-(di-n-propylamino)tetralin) (10 μg/kg) or S-15535 (1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-(2,3-dihydro-1h-inden-2-yl)-piperazine) (30 or 300 μg/kg) for 4 days postnatal day (P)28–31). (a) 8-OH-DPAT-pretreated adolescents showed enhanced quinpirole (0.4 mg/kg)-induced locomotion compared with saline pretreatment controls (+++p<0.0001 vs saline). Pretreatment with S-15535 (30 and 300 μg/kg), a presynaptic agonist did not enhance quinpirole-induced locomotion. (b) Although there was a drug effect for stereotypy for 8-OH-DPAT- and S-15535-pretreated animals, there were no effects of pretreatment. n=6–12 per group. (c) Quinpirole induced an erectile response in adolescent animals. *p<0.5, **p<0.001 vs vehicle. However, 8-OH-DPAT and S-15535 pretreatment did not enhance quinpirole-induced penile erection. n=4–9.