Figure 3.

Non-associative learning of HBIR in Mecp2^tm1.1Jae mice. Top two panels are integrated phrenic recordings in a representative animal. Bottom panels are group averaged data (means ± SD) for T_E and respiratory frequency normalized with respect to corresponding baseline values, plotted at selected time points before, during, and after vagal stimulation. (A) Wild-type female mice before and after dizocilpine treatment. (B) Heterozygous asymptomatic and symptomatic female mice. Dizocilpine had no effect in symptomatic mice (p > 0.1, 2-tailed paired t-test).