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. 2011 Mar 2;31(9):3328–3335. doi: 10.1523/JNEUROSCI.5936-10.2011

Figure 2.

Figure 2.

L-LTP requires protein synthesis and gene transcription. A, Summary results showing changes of fEPSP slopes before and after three episodes of TBS (spaced by 5 min) when protein translation inhibitor anisomycin (25 μm) was applied to the bath solution for 40 min, beginning at 10 min before the induction protocol (as indicated by the shadowed bar). The value of fEPSP slope represents the average over 5 min bins. The E-LTP was not affected (1.32 ± 0.08; n = 7), but L-LTP was abolished (0.96 ± 0.06; p = 0.009 vs E-LTP, paired t test). B, Similar to A, except that the gene transcription inhibitor actinomycin D (25 μm) was applied instead of anisomycin. Averaged amplitudes of E-LTP and L-LTP were 1.22 ± 0.07 and 1.00 ± 0.09 (n = 5; p = 0.05, E-LTP vs L-LTP), respectively.