Table 1.
Demographics of subjects.
| Group | All subjects | NC | MCI | AD |
|---|---|---|---|---|
|
n |
793 | 228 | 387 | 178 |
|
Age |
75.4±6.8‡‡ | 76.0±5.0 | 75.0±7.4 | 75.6±7.4 |
|
Sex (% male) |
58.3‡ | 52.2 | 64.6 | 52.2 |
|
Education |
15.6±3.0†† | 16.1±2.9 | 15.7±3.0 | 14.6±3.2 |
|
MMSE |
26.8±2.6* | 29.1±1.0 | 27.1±1.8 | 23.4±2.0 |
|
RAVLT delayed recall |
3.7±4.0* | 7.4±3.7 | 2.9±3.3 | 0.7±1.6 |
|
GDS |
1.4±1.4† | 0.8±1.1 | 1.6±1.4 | 1.6±1.4 |
|
NPI-Q Depression |
0.2±0.5** | 0.1±0.3 | 0.2±0.5 | 0.4±0.6 |
|
NPI-Q Apathy |
0.2±0.6* | 0.01±0.1 | 0.2±0.5 | 0.5±0.8 |
|
FAQ |
4.8±6.4* | 0.1±0.6 | 3.8±4.4 | 12.7±6.7 |
|
TMT-A |
46.6±25.5* | 36.3±13.0 | 44.2±21.7 | 64.8±34.5 |
|
TMT-B |
134.5±80.2* | 89.3±44.3 | 130.8±73.2 | 200.5±86.6 |
|
TMT-B-A |
88.0±66.9* | 53.0±38.8 | 86.6±63.1 | 135.8±74.3 |
| DSym | 37.4±12.9* | 45.8±10.2 | 37.0±11.1 | 27.6±12.5 |
AD (Alzheimer’s disease), DSym (Digit Symbol), FAQ (Functional Activities Questionnaire), GDS (Geriatric Depression Scale), MCI (mild cognitive impairment), MMSE (Mini-Mental State Examination), NC (normal control), NPI-Q Apathy (Neuropsychiatric Inventory brief questionnaire form, Apathy item), NPI-Q Depression (Neuropsychiatric Inventory brief questionnaire form, Depression item), RAVLT (Rey Auditory Verbal Learning Test), TMT-A (Trailmaking Test A), TMT-B (Trailmaking Test B), TMT-B-A (Trailmaking Test B minus Trailmaking Test A).
All values represent mean ± standard deviation (except n and sex).
p<0.0001 for NC vs. MCI, NC vs. AD, and MCI vs. AD.
p<0.005 for NC vs. MCI, NC vs. AD, and MCI vs. AD.
p<0.0001 for NC vs. MCI and NC vs. AD.
p<0.005 for NC vs. AD and MCI vs. AD.
p<0.01 for NC vs. MCI and MCI vs. AD.
p<0.05 for NC vs. MCI.