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. 2011 Feb 8;2:187. doi: 10.1038/ncomms1187

Figure 2. Loss of Brg1 leads to heart development defects in the zebrafish embryos.

Figure 2

(a, b) Lateral views at 5 dpf of WT (a) and brg1s481 (b) zebrafish embryos. Arrowhead in b shows pericardial oedema. (c, d) Frontal views of WT or brg1s481 zebrafish embryos at 48 hpf, showing myocardium, labelled with cmlc2:eGFP (c), and endocardium, labelled with flk1:eGFP (d). Original magnification: ×100. (e) Cardiac gene expression in WT and brg1s481 zebrafish embryos for indicated transcripts (left panels, top to bottom: cmlc2, amhc, bmp4 and notch1b; right panels, top to bottom: vmhc, nppa, tbx2b and ncx). White arrow shows normal absence of nppa at the atrioventricular (AV) junction, grey triangles show staining of pacemaker cells, red brackets show normal and expanded domains of AV canal markers (bmp4 and tbx2b). Original magnification: ×200.