Table 2.

Top 40 overrepresented Gene Ontology biological processes (FDR < 0.0001) in alternatively spliced genes in stage 4+ vs. 1- tumors

GO Term	# Gene	PValue
cell cycle process **	203	2.26E-15
mitotic cell cycle **	107	8.64E-15
cellular component organization and biogenesis *	572	1.07E-14
cell cycle **	230	1.33E-14
cell cycle phase **	115	2.03E-14
mitosis **	84	2.29E-14
cell division **	88	3.86E-14
M phase of mitotic cell cycle **	84	4.03E-14
M phase **	97	1.28E-13
organelle organization and biogenesis *	285	1.67E-13
developmental process	651	4.37E-12
nervous system development *	192	1.66E-10
multicellular organismal development	479	4.24E-10
cellular process	2167	4.71E-10
chromosome segregation	32	7.47E-10
anatomical structure development	441	1.43E-9
localization	610	1.10E-8
regulation of cell cycle **	135	1.11E-8
cell cycle checkpoint	30	1.15E-8
cytoskeleton organization and biogenesis *	134	1.41E-8
system development	364	1.93E-8
regulation of progression through cell cycle **	133	2.61E-8
DNA replication **	74	7.81E-8
synaptic transmission *	84	2.63E-7
transmission of nerve pulse	93	2.98E-7
establishment of localization	533	5.36E-7
intracellular signaling cascade	307	6.77E-7
cell proliferation	179	7.05E-7
transport	516	7.30E-7
mitotic sister chromatid segregation	18	7.33E-7
response to DNA damage stimulus **	86	1.18E-6
sister chromatid segregation	18	1.33E-6
biological adhesion *	173	1.67E-6
cell adhesion *	173	1.67E-6
DNA metabolic process **	188	2.59E-6
cell communication	747	7.35E-6
interphase	34	1.15E-5
DNA replication initiation	16	2.45E-5
DNA-dependent DNA replication **	36	2.54E-5
cell differentiation	355	2.55E-5

* GO terms that are also enriched in alternatively spliced genes in stage 4- vs 1- tumors.

** GO terms that are also enriched in differentially expressed genes in stage 4- vs 1- tumors.