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Model. Trafficking of PAM from the TGN to immature and mature secretory granules and through the endocytic pathway is compared in nontransfected AtT-20 cells (top), AtT-20 cells expressing PAM-1/K919R (top), and AtT-20 cells expressing PAM-1 (bottom). See text for discussion of model. LE, late endosome; EE, early endosome; ISG, immature secretory granule; MG, mature granule.
