Figure 4.
Systemic virus-specific humoral and cellular immune responses in controllers and progressors. (A) Antibody titer against the SIV-p27 and SIV-gp130 protein were determined in serum of controllers (blue) and progressors (red) by ELISA. (B) INF-γ secreting lymphocytes as determined by ELISpot assay are shown as the number of spot forming cells (SFC) per 106 PBMC after stimulation with viral peptide pools SIV-Gag, SIV-Tat, SIV-Nef and SIV-Env in controllers (blue) and progressors (red). Horizontal lines represent the mean of each group and P-values were calculated with the Mann-Whitney's U-test (*P < 0.05 and **P < 0.01).