Table 1.
Summary of microarray data for enzymes associated with choline metabolism
| Enzyme type | Gene symbol | Gene title | Percentage control | FDR |
|---|---|---|---|---|
| Choline transport | SLC5A7 | Solute carrier family 5 (choline transporter), member 7 | 101 | 0.91 |
| SLC44A1 | Solute carrier family 44, member 1 | 154a | 2.10 × 10-6 | |
| SLC22A1 | Solute carrier family 22 (organic cation transporter), member 1 | 99 | 0.97 | |
| SLC22A2 | Solute carrier family 22 (organic cation transporter), member 2 | 97 | 0.81 | |
| Choline kinase | CHKA | Choline kinase alpha | 109 | 0.2 |
| CHKB | Choline kinase beta | 102 | 0.86 | |
| CTP:PC cytidylyltransferase | PCYT1A | Phosphate cytidylyltransferase 1, choline, alpha | 101 | 0.92 |
| PCYT1B | Phosphate cytidylyltransferase 1, choline, beta | 109 | 0.35 | |
| Diacylglycerol choline-phosphotransferase | CHPT1 | Choline phosphotransferase 1 | 146a | 2.4 × 10-4 |
| Phospholipase A | PLA1A | Phospholipase A1 member A | 121a | 0.05 |
| PLA2G1B | Phospholipase A2, group IB (pancreas) | 105 | 0.67 | |
| PLA2G2A | Phospholipase A2, group IIA (platelets, synovial fluid) | 101 | 0.96 | |
| PLA2G2C | Phospholipase A2, group IIC | 104 | 0.83 | |
| PLA2G2D | Phospholipase A2, group IID | 98 | 0.83 | |
| PLA2G2E | Phospholipase A2, group IIE | 98 | 0.91 | |
| PLA2G3 | Phospholipase A2, group III | 99 | 0.18 | |
| PLA2G4C | Phospholipase A2, group IVC (cytosolic, calcium-independent) | 75a | 0.0043 | |
| PLA2G4E | Phospholipase A2, group IVE | 101 | 0.95 | |
| PLA2G4F | Phospholipase A2, group IVF | 82a | 0.018 | |
| PLA2G5 | Phospholipase A2, group V | 97 | 0.87 | |
| PLA2G6 | Phospholipase A2, group VI (cytosolic, calcium-independent) | 129 | 0.0067 | |
| PLA2G7 | Phospholipase A2, group VII | 112 | 0.3 | |
| PLA2G10 | Phospholipase A2, group X | 712a | 1.60 × 10-8 | |
| PLA2G12A | Phospholipase A2, group XIIA | 87a | 0.03 | |
| PLA2G12B | Phospholipase A2, group XIIB | 106 | 0.51 | |
| PLA2G15 | Phospholipase A2, group XV | 139 | 0.00043 | |
| PLA2G16 | Phospholipase A2, group XVI | 131 | 0.0021 | |
| Phospholipase | PLD1 | Phospholipase D1, phosphatidylcholine-specific | 137a | 0.0038 |
| PLD2 | Phospholipase D2 | 106 | 0.68 | |
| PLD3 | phospholipase D family, member 3 | 179a | 7.80 × 10-7 | |
| PLD4 | Phospholipase D family, member 4 | 106 | 0.68 | |
| PLD5 | Phospholipase D family, member 5 | 116 | 0.1 | |
| PLD6 | Phospholipase D family, member 6 | 82a | 0.0036 | |
| Lysophospholipase | LYPLA1 | Lysophospholipase I | 90 | 0.13 |
| LYPLAL1 | Lysophospholipase-like 1 | 88 | 0.18 | |
| LYPLA2 | Lysophospholipase II | 90 | 0.14 | |
| Glycero phosphocholin phosphodiesterase | GDPD1 | Glycerophosphodiester phosphodiesterase domain containing 1 | 106 | 0.64 |
| GDPD2 | Glycerophosphodiester phosphodiesterase domain containing 2 | 228a | 1.2 × 10-6 | |
| GDPD3 | Glycerophosphodiester phosphodiesterase domain containing 3 | 142a | 2.6 × 10-7 | |
| GDPD5 | Glycerophosphodiester phosphodiesterase domain containing 5 | 116 | 0.18 | |
| GDE1 | Glycerophosphodiester phosphodiesterase 1 | 112 | 0.062 |
aThese enzymes had a statistically significant (false discovery rate [FDR] less than or equal to 0.05) modulation in expression with 17-allyamino-17-demethoxygeldanamycin (17-AAG) treatment.