Table 2. Representative Quotes from Target Populations.

Theme	Representative Quotes	Group
1. Awareness	1. “Well, I have heard about it through a [local NGO]…they talked about some pre-exposure pills studies. And I know it was an antiretroviral and I know it is being used as a treatment.”	TG
2. Attitudes/ Expectations	2. “I think that if you put it right next to your night table, when you go to bed, for you to take it next to the night table, with your little glass of water and take it.”	FSW
	3. “I think that at the beginning yes, a week and that, but from there on out, they won’t take it and that’s that.”	TG
	4. “Well, if I am a person who has continuous [sexual] relationships yes, I’d take it, but if I don’t…why would I take it?”	MSM
	5. “…there’s also some people who suffer from high blood pressure, or who are diabetic, so [an exam would be necessary]…so that that kind of problem won’t exist with the pills.	FSW
	6. “If it’s going to have a lot of side effects in my body, I would leave it, I wouldn’t accept it.”	TG
	7. “…on Saturdays, if you have a party let’s say, you know you are going to drink and then you don’t take the pill.”	MSM
	8. “…well we will take care of ourselves and see that everyone takes it, because if we get infected we could infect others.”	FSW
	9. “It would be good when I am drunk and suddenly I don’t use the condom or it breaks.”	TG
	10. “I think that most of my friends are going to want to take it…and be more secure when a “one-night stand” appears.	MSM
3. Social/ Community Concerns	11. “I may tell the ones who are in this business, but not to others who aren’t.”	FSW
	12. “I would tell my transvestite friends about the treatment.”	TG
	13. “If I tell you that I am starting to take PREP, I would say that it is my own caring about myself, something which is only mine.”	MSM
	14. [“I would not tell my clients”]… because they may feel scared.	FSW
	15. “If it is just a “one-night stand”, no.”	MSM
	16. “I think that there would be some kind of rejection from my family…they would think I am a promiscuous person.”	MSM
4. Concerns about health care professionals	17. “There is an order from [the Public Health Department to conduct] workshops for all the personnel…because complaints were received from girls who had been psychologically mistreated.	FSW
	18. “It’s because of the stigma that they have with us, because we are transvestites, because gays and sex workers have HIV. There are still medical personnel who keep on thinking like that and with that discrimination, they aren’t mentally skilled to treat us.”	TG
5. PrEP’s ideal characteristics	19. “In the health center, because medicines are usually of the same quality and they are a little bit cheaper. In the drugstores, there are differences between one and the other; you have to look for the cheapest…	FSW
	20. “…if it were available at any drug store, there could be people who misuse it…and they wouldn’t take care of themselves.”	TG
	21. “…better in the Health Center, because sometimes people don’t go to the drugstores…in their neighborhood…because they are afraid of being identified as a person who has sexual relationships.”	MSM
	22. “[I prefer that they are free]… that they are like the contraception pill they give us in the health centers.”	FSW
	23. “[If free]…they would get used to have it for free all the time and when it is unavailable, they just won’t buy it.”	MSM
	24. “Yes, of course [I would pay for PrEP]…something that says that at least I am paying some of my own money…for my health.”	MSM
	25. “I think that [I would use it] until I stop working.”	FSW
	26. “To me, forever, because if I have a sexual intercourse I need it. But I would take it all my life while I have sexual activity….”	MSM
	27. “A hundred percent.”	TG
	28. “It would have to be 100% effective, I think that everyone would demand 100%”	MSM
	29. “[Every day] because you go to work but if you don’t work, you have to take it the same, yes everyday…”	FSW
	30. “I think that it wouldn’t work taking the pills every day because most people are not like that…they live in the moment. But the idea of taking it once a month, or every three months. I think that they could do it as if it were a contraceptive pill.”	TG
	31. “If they ask me to choose, I’d rather have it weekly or twice a week, by tablet, by capsule, by shot or whatever, it is far more likely than doing it daily.”	MSM
	32. “When you are in the moment having sex, you forget and then suddenly you don’t take it…you’re not going to be carrying your little bag with your pill in it [laughs] at the disco!”	MSM
	33. “Yes, but it could also be through the psychologist who talks to us, orientates us and gives us information.”	FSW
	34. “…your doctor or your counselor is going to tell you something or ask you questions like, ‘How are you feeling? How has your body reacted?’ I think that is a good thing and it should be like that too.”	TG
	35. “I think that it should be right there with the doctor or the counselor who delivers the pills directly. It should be the doctor because you enter his office and nobody knows what you are there for.”	MSM
6. Behavior changes after PrEP	36. “[Behaviors would not change], because that is only for HIV.”	FSW
	37. “I think that they would take the pills but they wouldn’t use the condom anymore.”	TG
	38. “If you tell someone, ‘Look, take this pill and it will prevent you from getting HIV,’ I can assure you that the next day, that person won’t use a condom anymore.”	MSM
	39. “There should be a lot of information and say that it is something additional to the condom and which is going to give you some extra protection;…if you tell them that [PrEP] is 100% secure, they won’t use [a condom] anymore.”	MSM