FIGURE 9.
Cytotoxic granule and cytokine production by kidney-infiltrating NK cells in MRL/lpr mice. Kidney MNCs isolated from MRL/mp and predisease and diseased MRL/lpr mice were stimulated with PMA + ionomycin for 4 h. A, Representative graphs show IFN-γ, granzyme B, and perforin expressed by kidney NK cells in MRL/mp and predisease and diseased MRL/lpr mice. B, Statistical analysis of the expression of IFN-γ, granzyme B, and perforin in NK cells from MRL/mp and predisease and diseased MRL/lpr mice; means ± SEM are displayed. Significance was determined using one-way ANOVA, followed by the Bonferroni post hoc test.