Table 2.
Subject demographics for all autopsy subjects by Braak NFT stage.
| Braak NFT Stage
|
|||||||
|---|---|---|---|---|---|---|---|
| 0–I (n=7) | II (n=9) | III (n=16) | IV (n=11) | V (n=31) | VI (n=27) | P-value | |
| Median (range) age at scan, y | 86 (53, 95) | 78 (72, 90) | 86 (72, 100) | 87 (81, 93) | 85 (59, 98) | 81 (49, 93) | 0.03 |
| Median (range) age at death, y | 91 (57, 101) | 81 (74, 94) | 89 (74, 103) | 88 (82, 94) | 86 (60, 100) | 83 (51, 94) | 0.028 |
| No. females (%) | 6 (86) | 6 (67) | 11 (69) | 4 (36) | 17 (55) | 18 (67) | 0.34 |
| Median, (range) education, y | 16 (12, 16) | 15 (12, 20) | 12 (8, 20) | 16 (7, 18) | 15 (8, 20) | 15 (8, 18) | 0.75 |
| APOE ε4 carriers (%) | 2 (29) | 2 (22) | 5 (31) | 6 (55) | 16 (53) | 17 (68) | 0.086 |
| Hippocampal W-score | −0.4 (−1.8, 1.2) | 0.2 (−1.2, 0.8) | 0.1 (−2.6, 3.1) | −1.1 (−2.6, 1.9) | −1.7 (−2.8, 3.1) | −1.7 (−2.8, 0.4) | 0.002 |
| Median (range) MMSE | 30 (27, 30) | 29 (26, 30) | 27 (18, 30) | 27 (23, 30) | 22 (12, 29) | 14 (7, 29) | <0.001 |
| *Median (range) CDR – SB | 0.0 (0.0, 0.0) | 0.0 (0.0, 3.0) | 0.0 (0.0, 8.0) | 1.0 (0.0, 17.0) | 7.0 (0.0, 18.0) | 10.0 (1.5, 18.0) | <0.001 |
| *Median (range) time to death from scan, y | 5.2 (3.7, 10.5) | 2.4 (1.2, 4.1) | 2.0 (0.1, 4.0) | 1.6 (0.7, 3.9) | 1.8 (0.2, 4.0) | 2.3 (0.6, 3.9) | <0.001 |
*
The cognitive test scores correspond with the MRI visit.
MMSE = Mini-Mental Status Examination; CDR-SB = Clinical Dementia Rating sum of boxes;