Figure 2:

StateCharts model of an autonomous pancreatic cell. (A) The cell is composed of a nucleus and a membrane and additional parts that control differentiation and proliferation. The Nucleus contains parts that follow the expression state of a few genes (Exp. or Unexp.), and the Membrane contains parts that follow the state of receptors and controls motion. (B) A histological cross-section of the pancreas (left), the emerging structure in the model at approximately the same developmental day (middle), and the result of an in silico experiment, in which the aorta was disabled, leading to a complete loss of structure (right) [8]. Figure reproduced with permission from Setty et al. [8].