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A) CT reconstruction of rat skull, with location of the craniotomy shown in red. B) Rats had a 3 mm diameter burr hole with the center positioned −3.2 mm from bregma, and 2 mm lateral to bregma cut via trephination. C) The craniotomy was replaced with 1 μl of adhesive (n = 8). Additional sham animals had the craniotomy replaced without adhesive (n = 4). Scalebar in C, same as B, and = 5 mm.
