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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Nat Med. 2011 Apr 17;17(5):596–603. doi: 10.1038/nm.2356

Figure 2.

Figure 2

LIGHT-deficient mice are resistant to airway remodeling induced by HDM. WT and Tnfsf14−/− mice received HDM intranasally once per week for 3 weeks, then twice per week for 4 weeks. Mice were killed 1 day after the last challenge. (a) Lung sections stained with Masson's trichrome (top) and collagen-1 (middle) and scoring for fibrosis (bottom left, n = 35–36 airways per group, means ± s.e.m., Mann-Whitney test). Total lung collagen was also measured (bottom right, eight mice per group, means ± s.e.m., Mann-Whitney test). (b) Peribronchial smooth muscle area (left, n = 34–35 airways per group, means ± s.e.m., Mann-Whitney test) and lung sections stained for α-smooth muscle actin (right). Levels reflect those above lung measurements from naive mice (a and b). (c) Invasive lung function test and resistance after challenge with 48 mg ml−1 methacholine (means ± s.e.m., Mann-Whitney test from six or seven mice per group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Scale bars, 100 μm.