Table 1.
DPC* | Type | Pathological findings† | ||
---|---|---|---|---|
Lung | Inguinal Lymph Nodes | Heart | ||
14 | I | Moderate focal/multifocal bronchointerstitial pneumonia (3/3) | Lymphadenopathy (3/3) | Mild multifocal perivascular lymphohistiocytic myocarditis (1/3) |
II | Moderate diffuse/multifocal bronchointerstitial pneumonia (2/3) | Lymphadenopathy (3/3) | Mild multifocal perivascular lymphohistiocytic myocarditis. (3/3) | |
Control | No lesions (2/2) | No lesions (2/2) | No lesions (2/2) | |
21 | I | Moderate diffuse interstitial pneumonia (2/2), moderate peribronchiolar and perivascular lymphohistiocytic cuffing (2/2) | Lymphadenopathy (2/2) | Mild multifocal perivascular lymphohistiocytic myocarditis (1/2) |
II | Mild to moderate diffuse interstitial pneumonia (2/2), severe peribronchiolar and perivascular lymphohistiocytic cuffing (1/2) | Lymphadenopathy (2/2) | Very mild multifocal perivascular lymphohistiocytic myocarditis (1/2) | |
Control | No lesions (1/1) | No lesions (1/1) | No lesions (1/1) |
* days post challenge
† No lesions were observed in liver, spleen, kidney and ileum.