Table 2. Causes of serious clinical events during 6 months follow-up on antituberculous treatment in 167 HIV-infected and 86 HIV-uninfected individuals.
| HIV-infected (n = 167) | HIV-uninfected (n = 86) | |
| Total number of serious adverse events | ||
| in number of patients (pat) | 77 events in 58 pat | 6 events in 6 pat |
| Concomitant infection | 31 (19%) | 2 (2%) |
| Confirmed infectiona | 9 | - |
| Suspected infectionb | 22 | 2 |
| Drug-induced liver toxicity | 22 (13%) | 2 (2%) |
| Paradoxical reactions/TB IRIS c | 21 (13%) | 1 (1%) |
| probable | 12 | 1 |
| possible | 9 | - |
| Treatment failure (multidrug-resistant TB) | - | 1 (1%) |
| Miscellanous | 5 (3%) | - |
| Suspected lymphoma | 2 | - |
| Suspected Kaposi's sarcoma | 1 | - |
a
illnesses with identified etiologic agent were: Klebsiella pneumoniae bacteremia (2), Staphylococcus aureus bacteremia (1), Klebsiella pneumoniae urosepsis (2), cryptococcal meningitis (1), zona ophtalmica (1), Plasmodium falciparum malaria (1), Escherichia coli dysentery (1).
b
in most cases no etiologic agent was identified including ilnesses such as hepatic abscess, enteritis, cholangitis, bronchopneumonia, urosepsis.
c
immune reconstitution inflammatory syndrome (IRIS) is used according to consensus case definitions for resource-limited countries [16]; paradoxical reaction is the term used for HIV-uninfected persons.