Table 6. Inhibition of HeLa cell toxicity by attenuated Y. pestis in the presence of selected small molecule inhibitors.
Inhibitor | Inhibition at 50 µM | Inhibition at 10 µM |
ID | % | % |
7086 | 20 | 0 |
7832 | 30 | 0 |
7812 | 0 | 0 |
The HeLa cells were incubated with attenuated Y. pestis KIM19 strain in the presence of small molecules in DMEM medium supplemented with 10% FBS as described under Materials and Methods. Cell toxicity was scored by calculating the percentage of rounded versus the squamous cells under a microscope. Only data for molecules showing 10% or more inhibition of cell rounding at 50 µM inhibitor concentration are shown.