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. 2011 May 18;6(5):e19444. doi: 10.1371/journal.pone.0019444

Figure 2. Metabolic parameters decline linearly with age in a typical JK1107 cohort.

Figure 2

(A) Age-dependent decline in ATP content and linear regression. Best linear fit (R squared 0.86) and 95% confidence band. Slope statistically significantly different from zero (P<0.0001). (B) Age-dependent decline in oxygen consumption, normalised to worm protein. Decline in oxygen consumption was statistically significant (P = 0.003, ANOVA with Tukey's post-test). (C) Age-dependent decline in mtDNA copy number per worm and linear regression. Best linear fit (R squared 0.98) and 95% confidence bands. Slope statistically significantly different from zero (P<0.01). (D) Age-dependent loss of the mitochondrial membrane lipid cardiolipin in C. elegans total lipid extract (n = 3 independent extractions for each time point). Total CL content clearly declines with age (P<0.005). Lipid content is expressed as relative abundance of phosphatidylcholines (PC), phosphatidylethanolamines (PE) and Cardiolipin (CL), normalised to PC content of young worms.