Fig. 3.

The Min mutation exacerbates hippocampal abnormalities in Lis1+/− BL/6 embryos and results in enlarged ventricles. WT = Wild type; LM = LisMin. A–D Embryonic day 19 embryos from a late-generation cross do not exhibit outward signs of hydrocephalus. E–H Hematoxylin-eosin staining of coronal brain sections of all 4 genotypes revealed that double heterozygotes, but not other genotypes, had enlarged ventricles at this embryonic stage. I–P Compound heterozygotes also had severer neuronal positioning defects in the hippocampus. M–P Enlargements of the regions indicated by the boxes in panels I–L.