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A) Organization of cytosolic domains of the L-type calcium channel. The carboxyl-terminal domain is cleaved in approximately ½ resulting in a mobile distal C-terminus (DCT) separate from proximal C-terminus (PCT) of the pore-forming domains of channel. The arrow represents akap (ref) aiding dCT – PCT interaction. Asterisks (*) show phosphorylation sites.
B) Relationship of exon usage to PCT and DCT. The consensus calpain cleavage site is encoded within exon42.
