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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Alcohol Clin Exp Res. 2011 Feb 25;35(6):1160–1170. doi: 10.1111/j.1530-0277.2011.01449.x

Fig. 3.

Fig. 3

Mean (±SE) percent freezing during the 5 minute test for the context preexposure facilitation effect (CPFE) in Experiments 2a and 2b. In Experiment 2a (PD7-9 exposure, left panel), Groups UD (undisturbed) and SI (sham intubated) demonstrate the CPFE whereas Group 5.25g does not. In the UD and SI control groups, rats preexposed to the training context (Pre, filled bars) show enhanced contextual freezing compared to their counterparts preexposed to an alternate context (No Pre, clear bars). In contrast, rats exposed to 5.25g of ethanol over PD7-9 [5.25g (PD7-9)] show little contextual freezing regardless of preexposure condition. In Experiment 2b (PD4-6 exposure, right panel), all treatment groups (Groups UD, SI & 5.25g) preexposed to the training context (Pre, filled bars) show the CPFE compared to No Pre controls. Thus, alcohol exposure over PD7-9 disrupts the CPFE, while exposure over PD4-6 does not. For PD7-9, Groups UD-Pre (n=8) and UD-No-Pre (n=9); Groups SI-Pre (n=13) and SI-No-Pre (n=12); Groups 5.25g-Pre (n=11) and –No-Pre (n=11). For PD4-6, Groups UD-Pre (n=9) and –No-Pre (n=9); Groups SI-Pre (n=7) and –No-Pre (n=9); and Groups 5.25g-Pre (n=10) and –No-Pre (n=9).