Table 2.
Substrate | Uptake by transfectants (dpm/µg) | ||||
---|---|---|---|---|---|
Vector | BOCT1 | BOCT2 | OCT1 | OCTN2 | |
MPP+ | 9.3 ± 0.8 | 9.9 ± 0.7 | 9.0 ± 0.4 | 372 ± 12* | 16.9 ± 0.4 |
TEA | 117 ± 3.9 | 112 ± 1.7 | 126 ± 7.5 | 223 ± 6.4* | 112 ± 7.2 |
Carnitine | 186 ± 16 | 209 ± 6.1 | 192 ± 9.6 | 241 ± 6.7 | 2,288 ± 84* |
Choline | 271 ± 5.2 | 265 ± 7.0 | 272 ± 20 | 510 ± 8.8* | 297 ± 47 |
Histamine | 24.4 ± 7.7 | 9.1 ± 0.8 | 8.0 ± 1.1 | 95.7 ± 4.3* | nd |
Norepinephrine | 29.5 ± 1.1 | 35.2 ± 1.7 | 24.1 ± 1.0 | 159 ± 3.2* | nd |
Nicotinamide | 39.0 ± 10.9 | 32.1 ± 2.2 | 27.8 ± 5.1 | 130 ± 9.5* | nd |
Urate | 4.5 ± 1.5 | 7.4 ± 4.3 | 4.5 ± 0.13 | 4.6 ± 2.1 | nd |
Ascorbate | 9.0 ± 2.1 | 10.1 ± 1.0 | 5.5 ± 0.3 | 6.5 ± 0.7 | nd |
nd not done
Statistically significant from pFLAG vector, P < 0.05