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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2011 Feb 1;23(3):338–345. doi: 10.1016/j.ceb.2011.01.001

Figure 1. Relocalization of developmentally regulated genes.

Figure 1

Repressed genes often associate with the nuclear lamina at the nuclear periphery. Upon activation, these genes are often targeted to the nucleoplasm. Certain co-regulated genes, located on different chromosomes (chromosome territories represented as blue and pink zones) can colocalize with each other at transcription factories (yellow), located between territories. The colocalization of certain genes requires transcriptional activator (Klf1; green protein) that localizes to a subset of transcription factories [●●37]. Colocalization may promote expression of co-regulated genes by either concentrating factors that promote their expression or by allowing escape from repressive interactions with the nuclear lamina.