Table 4.

Change in minimal medial joint space width (mJSW), medial compartment cartilage thickness, and ordered values of subregional cartilage thickness (ThCtAB) change over 12 months in knees without baseline JSN (n=143) and with baseline JSN (n=147) for which longitudinal mJSW and the MRI outcomes were available.

	no-JSN			JSN			Between-Group
	MC [µm]	SD [µm]	MC [%]	MC [µm]	SD [µm]	MC [%]	DIFF [µm]	CI [µm]	p-value	SL
mJSW	−81	575	−1.7	−129	654	−3.3	48	−94 / 190	.386	.050
MFTC	−18	113	−0.5	−59	142	−1.7	41	11 / 70	.007*	.025
MT	−4	50	−0.2	−12	59	−0.7	8	−5 / 21	.160	.013
cMF	−14	83	−0.7	−47	110	−2.7	32	10 / 55	.002*	.013
mOV 1	−102	107	−5.1	−146	152	−8.2	43	13 / 74	5.1E−4*	6.3E−3
eOV 1	−140	110	−6.4	−198	169	−10.4	58	25 / 91	2.1E−5*	2.9E−3

MC = mean change in µm or %, SD = standard deviation, DIFF = mean difference between changes, CI = 95% confidence intervals of differences between changes (lower / upper limit), SL = Significance level after Bonferroni-Dunn correction: The significance (p value) of the differences between changes in JSN and no-JSN knees was computed using non-parametric Wilcoxon rank-sum tests and is reported in the table without adjustment for multiple comparisons. Parameters showing significant differences after Bonferroni-Dunn correction (p<0.025 for compartments, p<0.0125 for cartilage plates, p<0.0063 for medial, and p<0.0031 for extended ordered values) are marked with *.

Medial ordered value (OV) 1 = subregion showing the most negative change (decrease in ThCtAB) in the medial femorotibial compartment of each subject. Extended OV 1 = subregion showing the most negative change (decrease in ThCtAB) in the medial or the lateral femorotibial compartment of each subject.