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. Author manuscript; available in PMC: 2011 May 19.
Published in final edited form as: Circ Cardiovasc Genet. 2008 Oct;1(1):51–57. doi: 10.1161/CIRCGENETICS.108.813337

Table 1.

NHLBI Programs in Genomic Research

Program Objective Subjects and Population(s) Selected CVD, Lung, and
Blood Phenotype(s)
Candidate Gene Association
Resource (CARe)		 Genomewide association study
in over 10,000 African
American subjects.
Candidate gene association
Study of ~50,000 SNPs in ~
2,000 genes implicated in
CVD.		 GWAS in >10,000 African
American subjects from five
cohorts.
Candidate gene studies in
>48,000 subjects from nine
cohorts. Cohorts include:
ARIC, CARDIA, CFS, CHS,
CSSCD, FHS, JHS, MESA
and SHHS		 Aging, anthropometry, atrial
fibrillation, blood biomarkers,
blood pressure/hypertension,
coronary heart
disease/myocardial infarction,
cardiac ultrasound
measures/heart failure,
diabetes, kidney disease, lipids,
pulmonary function, sleep,
stroke, subclinicla
atherosclerosis, peripheral
arterial disease.
SNP Typing for Association
with Multiple Phenotypes from
Existing Epidemiologic Data
(STAMPEED)		 13 GWAS projects to identify
genetic variants related to heart,
lung, and blood disorders and
their risk factors by utilizing
genome-wide association
studies in existing human
studies		 GWAS studies in multiple
existing human studies totaling
over 38,000 subjects.		 Aging, asthma, coronary heart
disease/myocardial infarction,
stroke, platelet function,
hematopoietic cell transplant
outcomes, subclinical
atherosclerosis, sickle cell
anemia outcomes, aging
SNP Health Association
Resource (SHARe)		 GWAS project in large NHLBI
cohorts studies to identify
genetic variants related to heart,
lung and blood disorders and
their risk factors.		 Framingham Heart Study
SHARe: GWAS in over 9,400
subjects from three generations
of the Framingham Heart Study
SHARe Asthma Research
Project (SHARP): GWAS in
~5,000 subjects from
asthma cohorts.		 Aging, anthropometry, atrial
fibrillation, blood biomarkers,
blood pressure/hypertension,
coronary heart
disease/myocardial infarction,
cardiac ultrasound
measures/heart failure,
diabetes, kidney disease, lipids,
pulmonary function, sleep,
stroke, subclinical
atherosclerosis, peripheral
arterial disease.
Asthma and asthma-treatment
response.
Enhancing Development of
Genome-wide Association
Methods (ENDGAME)		 Consortium of 11 research
groups to develop and test
innovative, informative, and
cost-effective study designs and
analytical strategies for
performing GWAS on complex
diseases.
Women’s Health Genome
Study		 GWAS to identify genetic
variants related to
cardiovascular disease, cancer
and selected risk factors.		 Up to 28,000 women
participants in the Women’s
Health Study, a study cohort
which has been followed for
over a decade as part of a
randomized controlled study
for prevention of
cardiovascular disease and
cancer.		 Blood biomarkers,
hypertension, coronary heart
disease/myocardial infarction,
diabetes, lipids, stroke.

Abbreviations: ARIC: Atherosclerosis Risk in Communities, CARDIA: Coronary Artery Risk Development in Young Adults, CFS: Cleveland Family Study, CHS: Cardiovascular Health Study, CSSCD: Cooperative Study of Sickle Cell Disease, FHS: Framingham Heart Study, JHS: Jackson Heart Study, MESA: Multi-Ethnic Study of Atherosclerosis, SHHS: Sleep Heart Health Study.