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. Author manuscript; available in PMC: 2011 May 19.
Published in final edited form as: Semin Nephrol. 2010 Jul;30(4):409–417. doi: 10.1016/j.semnephrol.2010.06.007

Figure 2.

Figure 2

MYH9 protein and exon structure: mutations causing large platelet syndromes. The structures of nonmuscle myosin IIA and IIC are shown; each is a hexamer composed of two heavy chains (encoded by MYH9 in the case of myosin IIA), two essential light chains, and two regulatory light chains. The location of missense mutations in the myosin IIA molecule associated with autosomal-dominant MYH9 spectrum disorders are shown.