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. Author manuscript; available in PMC: 2011 May 19.
Published in final edited form as: Semin Nephrol. 2010 Jul;30(4):409–417. doi: 10.1016/j.semnephrol.2010.06.007

Table 2.

Epidemiologic Implications of MYH9 Kidney Risk Variant Haplotype

Cigarette Smoking MYH9 Kidney Risk Variants (2 copies) MYH9 Kidney Risk Variants (1 or 2 copies)
Attributable risk Lung cancer: males, 90%; females, 60% HIV-CG, 59%
FSGS, 56%
Hypertension-attributed ESKD, 20%		 HIV-CG, 100%
FSGS, 72%
Hypertension-attributed ESKD, 38%
Explained fraction Lung cancer, 12% HIV-CG, 10%
FSGS, 4%
Hypertension-attributed ESKD, 1%		 HIV-CG, 12%
FSGS, 5%
Hypertension-attributed ESKD, 2%

NOTE. Attributable risk is the proportion of disease incidence that would be removed from the population under consideration if a factor (exposure) were removed. Explained fraction is the proportion of disease incidence that is entirely explained by the factor under study, in the context of all known and unknown genetic, environmental, and stochastic factors that determine which individuals will develop the disease.