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. 2011 Feb 8;4(3):335–346. doi: 10.1242/dmm.006411

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — Developmental ethanol exposure reduces InR expression and InR mutants are sensitive to developmental ethanol toxicity.

(A) Developmental ethanol exposure reduces InR expression specifically in the larval brain. mRNA levels are expressed as fold difference relative to control larvae (Kruskal-Wallis test, n=3, *P=0.0369). (B) Heterozygous mutants for InR are sensitive to the decrease in eclosion induced by developmental ethanol exposure (Dunnett’s, n=6, *P<0.001).