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. 2011 Feb 8;4(3):335–346. doi: 10.1242/dmm.006411

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© 2011. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 6. — dilp2 expression rescues both sedation resistance and tolerance development. (A) dilp2 expression rescues ethanol-induced sedation resistance. Data are presented as difference in time to 50% sedation (ST₅₀) for ethanol-reared flies as compared with control flies of the same genotype. dilp2-GAL4/UAS-dilp2 flies do not display increased sedation resistance upon ethanol-rearing, whereas both genetic background controls show the expected increase in ST₅₀ (one-way ANOVA with Tukey HSD post-hoc analysis, n=12, *P<0.01). (B) dilp2 expression rescues ethanol-induced tolerance defects. Data are presented as the percent control tolerance (tolerance developed by ethanol-reared flies divided by tolerance developed by control flies of the same genotype multiplied by 100). Although both genetic background controls show a 40–50% reduction in tolerance when reared in ethanol, dilp2-GAL4/UAS-dilp2 flies develop normal levels of ethanol tolerance (one-way ANOVA with Tukey HSD post-hoc analysis, n=6, *P<0.05).