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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Cancer Res. 2010 May 11;70(11):4375–4384. doi: 10.1158/0008-5472.CAN-09-4403

Figure 6. ANK inhibits ILK dependent MCM7 phosphorylation and colony formation inhibition induced by ITGA7.

Figure 6

(A) ANK inhibits phosphorylation of MCM7 by ILK and reverses MCM7-chromatin association inhibition by ITGA7. PITT1 cells were infected with Ad-Gal or Ad-ANK, and stimulated with tetracycline to induce ITGA7 expression. MCM7 was then immunoprecipitated and blotted with anti-phospho-serine or anti-phospho-threonine antibodies. Chromatin association analyses were similarly performed as in figure 3. (B) ANK reverses ITGA7 tumor suppressor activity. PITT1 and PITT2 cells were infected with either Ad-GAL or Ad-ANK, and treated with or without tetracycline. Colony formation analyses were performed on these cells.