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. Author manuscript; available in PMC: 2011 May 19.
Published in final edited form as: Drug Discov Today Dis Mech. 2010 WINTER;7(3-4):e213–e218. doi: 10.1016/j.ddmec.2011.01.003

Figure 3. Potential role of cyclooxygenase-2s in obesity.

Figure 3

Cyclooxyganse-2 (COX-2) may contribute to increased inflammation and insulin resistance associated with obesity, possibly through increasing cytokine secretion or by increasing prostaglandin production from the macrophage. On the other hand, COX-2 may also act to increase brown adipocyte generation in white adipose tissue thus ameliorating obesity.