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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: Structure. 2011 Feb 9;19(2):265–276. doi: 10.1016/j.str.2010.12.005

Figure 6. N-Linker mediates cross-talk between two heterodimers in PKA RIα holoenzyme.

Figure 6

A. Binding cAMP molecule to CNB-A in a heterodimer (indicated by the red arrow) disrupts the R:C interface in the C-linker around the P+1 loop, αG-helix region (indicated by the red circle). B. Binding of the second cAMP molecule to the symmetry related R′-subunit disrupts the R′:C and R′:R interface in the N-linker area.