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. Author manuscript; available in PMC: 2012 Feb 9.
Published in final edited form as: Structure. 2011 Feb 9;19(2):265–276. doi: 10.1016/j.str.2010.12.005

Figure 7. Structural changes in the Phosphate Binding Cassette (PBC) in RIα (73-244):C holoenzyme.

Figure 7

A. Overlay of PBCs in cAMP-bound RIα (1RGS) (white) and RIα(91-244):C holoenzyme (3FHI) (golden). B. C-terminal part of the PBC in RIα(73-244):C holoenzyme (red) is distorted. The β4-β5 loop position in the new holoenzyme is also shifted. C. V182 from the “Base Binding Region” interacts with the A210-A211 region of the PBC, occluding cAMP binding. cAMP is modeled from the cAMP-bound RIα structure.