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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Clin Lipidol. 2010 Dec 1;5(6):867–897. doi: 10.2217/clp.10.67

Figure 3. Differential phospholipid-binding strategies by Sec14-like phosphatidylinositol transfer proteins.

Figure 3

Structure of Sfh1 bound to: (A) PtdIns (pdb 3B7Z); (B) PtdCho (pdb 3B7Z). (C) A description of the configurations of both phosphatidylinositol (PtdIns; gray) and phosphatidylcholine (PtdCho; black) in the Sfh1/Sec14-fold. The data are from crystals composed of approximately equal numbers of unit cells of Sfh1 bound to PtdIns and Sfh1 bound to PtdCho (pdb 3B7Z). The A10/T4 ‘helical gate’ that mediates lipid entry is in red, surrounding α-helices are in blue, the ‘tripod motif’ is in green and β-strands that compose the floor of the hydrophobic pocket are in yellow. The polar headgroups of PtdIns and PtdCho bind at distinct sites within the hydrophobic pocket, while the acyl chain space within the hydrophobic pocket overlaps for these phospholipids.