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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Environ Int. 2011 Apr 5;37(5):838–857. doi: 10.1016/j.envint.2011.02.010

Figure 5.

Figure 5

Connectivity of differentially expressed genes in the important signaling pathway following exposure of PCB 138 in human PBMC depicting the connectivity between genes expressed (≥1.0, t-test, p<0.001) and the important signaling pathways in human PBMC in vitro following exposure of PCB 138. Geometric figures in red denote up-regulated genes and those are green indicate down-regulation. The network shows genes mainly involved in cell cycle and cell signaling. Solid interconnecting lines shows the genes that are directly connected and the dotted lines signify indirect connection between the genes and cellular functions. Canonical functions that are highly represented are shown within the box (AMPK Signaling, Molecular mechanism of Cancer, Caveloar-mediated Endocytosis, Macropinocytosis, and Colorectal cancer metastasis signaling). Genes in uncolored notes were not identified as differentially expressed in our experiment and were integrated into computational generated networks based on evidence stored in the IPA (Ingenuity Software) knowledge memory indicating relevance of this network.