Table 3.

High-scoring networks (Score >10) identified by Ingenuity® Pathway Analysis in PCB 153 and PCB 138 exposure to Human PBMC. Top three (3) networks (out of 5) are represented here.

Network ID	Network	Association	Score	Focus Genes	Functions
1.	RPL23A (includes EG:6147) SPAG11B, TBX19, TCR, NCAM1, NFATC1, PDE4B, Pkc(s), PRTN3, RAB11FIP1RAF1, Ras, DUSP6, F2RL1, FGF9, FN1, HGF, IFNG, IL2, IL5, ITGA4, ITGB7, MAPK1, MIR122, AIF1, AKT3, Ap1, CALCA, CCL5, CD44, CTNNB1, CTNND2, CX3CR1, CXCL10, CXCR4	PCB 153	19	15	Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking
2.	LGALS3, LYN, NF2, P38 MAPK, PDGFRB, PLAUR, PLG, PTK2B, PXN, SPHK1, STAT3, TNF, EFNA3, ENPP2, EPHB2, FGFR2, IgG, IL2, IL8, IL13, IL1B, IL1R1, Interferon alpha, APP, ATP1B3, AZU1, C5AR1, CBL, CCL2, CCL5, CCL27, CDKN1A, CXCR4, DUSP5, TYK2	PCB 153	13	12	Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking
3.	ACTB, BAG1, FSH, ITPR1, MAPK6, PDXK, TLN1	PCB 153	10	6	Cancer, Cellular Movement, Molecular Transport
4.	NCF1C, NCLN, PDGFRB, PPARD, PRKCA, SEPP1SOCS1SRC, STAT1, STOML2,LDL, LGALS3, LGALS8, M6PR, MAPK3, MET, MMP2, MMP3, MMP1 (includes EG:4312), Akt, AKT2, Ap1, CD44, CHN2, CHRNA3, EGFR, EPO, ERBB2, Fibrinogen, IL13, IL18, ITGB1,	PCB 138	12	11	Cell Cycle, Cellular Movement, Cancer
5.	Vegf, ZEB1, NR0B1, PTGER2, RAB1A, RAD17, SGK1, SNAP23, STX4, STX6, TGFB1, TGFB2, TNF, TP53, DYRK3, E2F1, EZR, FAS, FOS, FOXO3, FSH, hCG, IgG, ITGB5, NFkB (complex), ACTA1, ACTA2, ATM, CCND2, CD46, CDKN1A, CHEK2, CREM, CTGF, CYP19A1	PCB 138	12	11	Cell Death, Hematological Disease, Immunological Disease
6.	STAT1, TGFB1, VTN MMP1 (includes EG:4312), MYC, NFkB (complex), OPRM1, PDGF BB, SERPINE1, SOCS1, HLA-DRA, IFNG, IL2, IL4, IL8, IL18, IL1B, INS, LDL, MAPK1, MAPK3, MBP, Akt, APP, C5, CASP1, CLU,CORO1C, CRP,CSH1,CXCL2,EPOR, FAS, GHRL	PCB 138	11	10	Antigen Presentation, Cell mediated Immune Response, Hormonal Immune Response,

Focus Genes are italicized