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Principle of reporter genes for gene expression. The reporter gene (red) is co-expressed with the gene of interest (green), often by using the same promoter for both genes. The reporter gene can be the HSV thymidine kinase (phosphorylating radioactive-labeled nucleoside-analog, which get trapped in the cell (A), a fluorescent protein like GFP (B), an intracellular target for a marker (C) or a cell membrane receptor as the transferin-receptor (D).
