Table 2.
Predictor | Adjustment variablesa | Cognitive measurement |
||||
---|---|---|---|---|---|---|
ADAS-Cog | MMSE | Auditory–Verbal Learning Test | Boston Naming | Trails B | ||
Predictor variable | ||||||
Amyloid-β1–42 | −0.14 | −0.14 | 0.04 | 0.12 | −0.11 | |
STAND | 0.07 | 0.01 | −0.04 | −0.16 | 0.04 | |
t-tau | 0.06 | 0.05 | −0.01 | −0.03 | 0.14 | |
WMH | 0.17 | 0.14 | 0.04 | 0.04 | −0.04 | |
AMNART | 0.16 | −0.37** | −0.05 | −0.31** | 0.07 | |
AMNART adjusted for biomarkers | ||||||
AMNART | Amyloid-β1–42 | 0.17 | −0.36** | −0.06 | −0.32** | 0.08 |
AMNART | STAND | 0.16 | −0.37** | −0.05 | −0.31** | 0.07 |
AMNART | t-tau | 0.16 | −0.37** | −0.05 | −0.31** | 0.06 |
AMNART | WMH | 0.17 | −0.36** | −0.05 | −0.32** | 0.07 |
AMNART | Amyloid-β1–42, t-tau, STAND and WMH | 0.18 | −0.36** | −0.06 | −0.34** | 0.07 |
Biomarkers adjusted for AMNART | ||||||
Amyloid-β1–42 | −0.15 | −0.13 | 0.05 | 0.15 | −0.11 | |
STAND | 0.07 | 0.00 | −0.04 | −0.17 | 0.04 | |
t-tau | 0.05 | 0.06 | −0.00 | −0.02 | 0.14 | |
WMH | 0.18 | 0.12 | 0.04 | 0.03 | −0.03 |
a Age and gender are included.
STAND = Structural Abnormality Index; WMH = white matter hyperintensity.
*P-value between 0.01 and 0.05.
**P-value < 0.01.