Table 2.
Secular trends in paediatric admissions to Kilifi District Hospital between 2002 and 2008 and the incidence of acute symptomatic seizures by malaria association
| Admission profiles | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | Total |
|---|---|---|---|---|---|---|---|---|
| Number of admissions from within and outside the DSS | 4851 | 5539 | 5056 | 4751 | 5016 | 4496 | 4348 | 34 057 |
| Number of admissions with history of seizures from within and outside DSS | 1310 | 1521 | 964 | 430 | 433 | 530 | 392 | 5580 |
| Number of MAS from the DSSa | 734 | 1028 | 392 | 230 | 207 | 79 | 110 | 2780 |
| Number of admissions with non-MAS from the DSSa | 271 | 246 | 326 | 200 | 219 | 249 | 282 | 1793 |
| Mean age (standard error) in months for MAS from the DSS | 30.2 (0.9) | 29.9 (0.7) | 29.7 (1.0) | 31.8 (1.3) | 35.1 (1.6) | 40.1 (2.7) | 32.9 (2.0) | |
| Mean age (standard error) in months for non-MAS from the DSS | 29.3 (1.6) | 30.1 (1.6) | 29.4 (1.7) | 26.5 (1.9) | 25.2 (1.7) | 27.1 (1.9) | 30.0 (1.6) | |
| Parasite prevalence (%) in the comparison group for this study | 16 | 46 | 33 | 24 | 18 | 6 | 6 | |
| Person-years | 85 827 | 89 592 | 97 099 | 1 00 303 | 1 03 492 | 1 05 289 | 1 07 451 | 6 89 053 |
| Previous study’s incidence of slide-positive admissions per 1000 (O’Meara et al., 2008) b | 17.2 | 18.4 | 11.3 | 7.3 | 5.8 | 3.4 | – | |
| Previous study’s parasite prevalence (%) in trauma patients (O’Meara et al., 2008)b | 19 | 24 | 13 | 11 | 7 | 1 | – | |
| Annual incidence of admissions with acute symptomatic seizures/100 000/year | ||||||||
| All MAS | 855 | 1147 | 404 | 229 | 200 | 75 | 102 | |
| All non-MAS | 316 | 275 | 316 | 197 | 206 | 200 | 260 | |
| CSE MAS | 139 | 180 | 117 | 61 | 52 | 26 | 28 | |
| CSE non-MAS | 54 | 40 | 89 | 47 | 53 | 49 | 55 | |
| Repetitive MAS | 432 | 569 | 192 | 119 | 101 | 39 | 50 | |
| Repetitive non-MAS | 164 | 132 | 159 | 75 | 96 | 89 | 107 | |
| Focal MAS | 136 | 101 | 38 | 25 | 25 | 5 | 7 | |
| Focal non-MAS | 54 | 26 | 30 | 29 | 30 | 13 | 30 | |
a Admission numbers as contained in the online admission database, of which 69 and 18 children did not show any evidence of seizures on review of clinical for the MAS and non-MAS groups, respectively. b These figures were part of another analysis (O′Meara et al., 2008). The annual population figures for children were made at the midpoint of the years of study by fitting a log-linear regression line through the observed population counts. CSE = Convulsive status epilepticus; DSS = the demographic surveillance system.