Table 4.
Comparison of clinical features and pathological comorbidities between cases with HS-Ageing and hippocampal sclerosis negative cases in two cohorts: UK-Alzheimer’s Disease Centre and Nun Study
| HS-Ageing | n | No HS-Ageing | n | P-valuea | No hippocampal sclerosis aged >89 years | n | P-value a | |
|---|---|---|---|---|---|---|---|---|
| UK-Alzheimer’s disease centre | ||||||||
| Age at death (mean years) | 87.7 | 44 | 82.0 | 521 | 93.4 | 107 | ||
| History of hypertension (%) | 48.4 | 31 | 55.3 | 309 | 0.571 | 59.5 | 111 | 0.308 |
| History of transient ischaemic attacks (%) | 10.7 | 28 | 10.1 | 277 | 1.000 | 14.9 | 94 | 0.760 |
| History of smoking (%) | 44.4 | 27 | 46.5 | 230 | 1.000 | 28.0 | 75 | 0.151 |
| History of brain trauma (%) | 16.7 | 30 | 14.0 | 272 | 0.782 | 10.8 | 93 | 0.521 |
| History of seizures (%) | 9.7 | 31 | 7.1 | 268 | 0.487 | 2.2 | 91 | 0.103 |
| Braak stage V or VI (%) | 54.6 | 44 | 51.1 | 521 | 0.754 | 36.5 | 107 | 0.047 |
| Lewy body disease (%) | 22.7 | 44 | 15.4 | 521 | 0.200 | 12.2 | 107 | 0.134 |
| Amyloid angiopathy (%) | 61.0 | 41 | 64.9 | 502 | 0.614 | 65.1 | 106 | 0.703 |
| Pale infarcts (%) | 6.8 | 44 | 7.1 | 521 | 1.000 | 9.5 | 107 | 0.757 |
| Haemorrhagic infarcts (%) | 4.6 | 44 | 5.8 | 521 | 1.000 | 7.5 | 107 | 0.724 |
| Lacunar infarcts (%) | 6.8 | 44 | 5.8 | 521 | 0.736 | 8.4 | 107 | 1.000 |
| Micro-infarcts (%) | 43.2 | 44 | 36.5 | 521 | 0.417 | 44.9 | 107 | 1.000 |
| Large infarcts (%) | 36.4 | 44 | 21.9 | 521 | 0.039 | 31.8 | 107 | 0.704 |
| Nun Study | ||||||||
| Age at death (mean years) | 92.8 | 56 | 89.5 | 470 | 93.6 | 241 | ||
| Lewy body disease (%) | 16.1 | 56 | 8.7 | 470 | 0.077 | 10.4 | 241 | 0.228 |
| Lacunar infarcts (%) | 46.8 | 47 | 31.1 | 437 | 0.034 | 37.3 | 212 | 0.249 |
| Large infarcts (%) | 17.0 | 47 | 17.8 | 437 | 1.000 | 17.5 | 212 | 1.000 |
a P versus hippocampal sclerosis (Fisher’s exact test).