Table 2.
Sequence learning-related activation responses in manifesting DYT1 carriers
Contrast | MNI coordinates |
Z-max | Cluster size | ||
---|---|---|---|---|---|
Brain region | x | y | z | ||
MSEQManifesting-DYT1 > CCWManifesting-DYT1 | |||||
Right dorsal premotor cortex (BA 6) | 18 | 16 | 56 | 5.16 | 486 |
Left dorsal premotor cortex (BA 6) | −30 | 6 | 62 | 4.19 | 160 |
Right inferior parietal lobule (BA 40/7) | 42 | −62 | 44 | 4.48 | 156 |
Left superior parietal lobule (BA 7/40) | −26 | −66 | 50 | 3.90 | 91 |
Right anterior cingulate cortex (BA 32) | 2 | 26 | 38 | 4.33 | 196 |
Right ventral prefrontal (BA 10, BA 46)a | 40 | 50 | 12 | 4.53 | 94 |
Right ventral prefrontal (BA 10)a | 28 | 64 | 2 | 4.36 | 85 |
Left cerebellar hemisphere (lobule VI)a | −32 | −66 | −26 | 4.56 | 99 |
VSEQManifesting-DYT1 > AVManifesting-DYT1 | |||||
Right dorsal premotor cortex (BA 6) | 46 | 14 | 52 | 4.61 | 402 |
Right inferior parietal lobule (BA 40/7) | 40 | −50 | 46 | 5.29 | 395 |
Left inferior parietal lobule (BA 40/7) | −38 | −50 | 52 | 5.83 | 414 |
Right Precuneus (BA 7) | 10 | −66 | 52 | 4.60 | 228 |
Right temporo-parietal cortex (BA 19, BA 39) | 36 | −78 | 36 | 4.02 | 149 |
Left cerebellar hemisphere (lobule VI/crus I) | −46 | −72 | −28 | 4.34 | 183 |
(MSEQManifesting-DYT1 > CCWManifesting-DYT1) ∩ (VSEQManifesting-DYT1 > AVManifesting-DYT1) | |||||
Right inferior parietal lobule (BA 40/7) | 40 | −60 | 44 | 6.33 | 139 |
Left inferior parietal lobule (BA 40) | −38 | −54 | 40 | 5.20 | 10 |
Right dorsal premotor cortex (BA 6) | 40 | 12 | 52 | 6.31 | 291 |
Left dorsal premotor cortex (BA 6) | −32 | 6 | 58 | 5.26 | 12 |
Left dorsal premotor cortex (BA 6) | −26 | 12 | 64 | 5.02 | 4 |
Right precuneus (BA 7) | 12 | −68 | 50 | 5.61 | 51 |
Right precuneus, angular gyrus (BA 7/39) | 42 | −76 | 34 | 5.30 | 23 |
Left superior parietal lobule (BA 7) | −28 | −80 | 42 | 4.95 | 5 |
Left posterior cerebellum (lobule VI) | −26 | −66 | −28 | 5.02 | 5 |
a False discovery rate corrected. P < 0.05; AV = audiovisual; BA = Brodmann area.