Table 4.

Correlations between sequence learning-related activation and measures of left cerebellar tract connectivity in manifesting-DYT1 subjects^a

Brain region	MNI coordinates			Z-max	Cluster size	VOI-based correlation in MSEQ
	x	y	z			R	P-value
Positive correlation
Left dentate nucleus	−24	−40	−32	4.67	523	0.42	0.05
Inverse correlation
Supplementary motor area, presupplementary motor area, cingulate gyrus (Right > Left; BA 6/32)	2	−22	60	5.68	3510	−0.74	<0.001
Right lateral prefrontal cortex (BA 9, BA 45)	60	22	26	5.74	184	−0.57	<0.01

a Left-hand columns represent the significant clusters identified using SPM voxel-wise regression of the regional cerebral blood flow scans acquired during VSEQ performance. Left cerebellothalamic connectivity values were entered as the covariate of interest in this analysis.

The right-most column represents the correlation coefficients (and P-values) for these regions computed using regional cerebral blood flow values for each region obtained from the corresponding MSEQ scans of these subjects. BA = Brodmann area; VOI = volume-of-interest.