Figure 3.

Design of experiments testing tumor homing of white adipose tissue cells and their effect on tumor growth. A: metronomic green fluorescent proteins (GFP) + white adipose tissue (WAT) administration: cultured cells are sc-injected (lower back) using metronomic cell injection regimen (104 cells/d) into mice xenografted with human tumors (upper back). B: WAT transplants: GFP+ WAT is implanted (1) into lean mice prior to tumor grafting (2), which allows us to track recruitment of implant-derived cells by tumor and to measure the resulting effect on cancer progression. Tumor growth is compared to that in control mice.