Table 4.

Predictors of survival after diagnosis of brain metastasis

Variablea	Unadjusted hazards ratio (95% CI)	P value	Adjusted hazards ratio (95% CI)	P value
Age	1.03 (1.01–1.05)	0.02	1.03 (1.00–1.05)	0.02
KPS	0.42 (0.22–0.81)	0.01	0.65 (0.32–1.29)	0.21
Number of BM	1.33 (0.83–2.12)	0.24	0.88 (0.52–1.51)	0.65
Extracranial disease	2.41 (1.39–4.16)	0.002	3.30 (1.70–6.41)	0.0004
Primary tumor	1.09 (0.67–1.80)	0.73	0.94 (0.55–1.63)	0.84
EGFR mutation	0.67 (0.42–1.07)	0.09	0.50 (0.30–0.82)	0.006

^aReference groups: KPS, Karnofsky performance status; KPS < 70; 1–3 BM; controlled or absent extracranial disease; controlled or absent primary tumor; no EGFR mutation.