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An example LOD profiles for various 5'SS ISEs/ISSs signals in vicinity of a weak 5'SS (with discrete score 1 out of 3 possible). Signal AAGGTAA is a core part of a strong canonical 5'SS and therefore is substantially depleted in vicinity of true exonic boundaries as potential competitor. The distinctive bell-shaped LOD profiles for GGGGTGGG and CGGGGGCG are from the well studied poly-G family of ISEs [31], known to form quadruplex structures [57].
