Table 2.

Number of predicted splicing events induced by the same number of disease associated and control SNPs randomly selected from the loci of 238 genes linked to ASD.

Type of event	997 SNPs			539 SNPs
	Alzheimer's associated	Control	Ratio	Breast cancer associated	Control	Ratio
Predicted exon corresponding to an annotated exon disappears	0	2	0	0	0	-
Predicted exon corresponding to an annotated exon changes a score	43	12	3.58	11	2	5.5
Predicted exon sharing a SS with an annotated exon changes a score	242	78	3.10	59	29	2.03
Predicted exon sharing a SS with an annotated exon disappears	23	4	5.75	6	1	6.00
New predicted cryptic exon is created sharing a SS with with an annotated exon	26	9	2.89	5	1	5.00
Predicted exon disappears	50	49	1.02	30	17	1.76
New predicted cryptic exon is created	50	46	1.08	24	25	0.96

Comparison is made in context of known annotated reference exons. Not all the originally available SNPs associated with a disorder mapped to loci of protein coding genes, therefore number of SNPs reported here is lower than originally obtained [see Subsection Constructing the test set].