Table 5.
Identification and annotation of new members of the acyl-adenylate superfamily.
| Subfamily | AMP-ligases (1499) | Hypothetical proteins (235) | Unnamed proteins (64) | Putative proteins (473) | Unknown proteins (5) |
|---|---|---|---|---|---|
| AcCS | 266 | 42 | 21 | 54 | 0 |
| 4CL | 12 | 7 | 0 | 11 | 1 |
| MCS | 151 | 16 | 4 | 23 | 0 |
| LCS | 1065 | 162 | 39 | 341 | 4 |
| Luciferase | 0 | 0 | 0 | 0 | 0 |
| NRPS | 5 | 8 | 0 | 44 | 0 |
| Total | 2276 | ||||
The numbers within parenthesis in the top row indicate total number of proteins in NR database which have been originally annotated as acyl-AMP ligases, putative proteins or unknown proteins due to lack of suitable tools for assigning substrate preference. The various rows indicate the number of such proteins which could be grouped into various subfamilies by our substrate specificity prediction methods.