Aligned (heavy atoms) bundles of the10 final NMR structures. RP hybrid DNA in red, SP hybrid DNA in blue, RNA shown in grey. Structures were generated by sampling 1/ps for the final 10ps of a 6.0 ns restrained solvated molecular dynamic simulation (rMD), followed by fully restrained minimization. RMSD of the heavy atoms were, RP hybrid 0.30 Å, SP hybrid 0.34 Å.