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Inhibition of AlkA by undamaged and abasic-containing DNA. Reactions contained 100 nM I•T 19u DNA, 2 nM AlkA, and the indicated concentration of abasic or undamaged (A•T) 25mer DNA inhibitor. Lines indicate the best fits to the equation for competitive inhibition and give Kd values of 61 ± 9 nM for undamaged DNA (●) and 2.8 ± 0.3 nM for abasic product (○; see inset).
